Verywell Health's content is for informational and educational purposes only. [4] In the colon, a low oxygen environment, you will find the anaerobic bacteria Peptostreptococcus, Bifidobacterium, Lactobacillus, and Clostridium. The formulation supplied in a multiple dose vial with a gray cap and label with a gray border IS NOT DILUTED PRIOR TO USE. An EUA is in effect for the duration of the COVID-19 EUA declaration justifying emergency use of this product, unless terminated or revoked (after which the product may no longer be used). The vaccine will be an off-white suspension. These mechanisms include phagocytosis, antimicrobial peptides called defensins, and the complement system. In the following analyses of Study 2 in adolescents 12 through 15 years of age (1,131 of whom received Pfizer-BioNTech COVID-19 Vaccine and 1,129 of whom received placebo), 98.3% of study participants had at least 30 days of follow-up after Dose 2. Enterotypes of the human gut microbiome. [37], Granulocytes are leukocytes that have granules in their cytoplasm. A severe allergic reaction would usually occur within a few minutes to 1 hour after getting a dose. Vial labels and cartons may state that after dilution, a vial contains 5 doses of 0.3 mL. Total cumulative time the vials are stored at -25C to -15C (-13F to 5F) should be tracked and should not exceed 2 weeks. Vials must be kept frozen and protected from light, in the original cartons, until ready to use. The immune system also plays a crucial role in embryogenesis (development of the embryo), as well as in tissue repair and regeneration. Mol Brain. Immune components and pathways are involved in regeneration as well, for example in amphibians such as in axolotl limb regeneration. Pulmonologists treat the cardio-pulmonary system, which consists of the heart, lungs, and organs involved in the respiratory process. [53] The speed of the response is a result of signal amplification that occurs after sequential proteolytic activation of complement molecules, which are also proteases. The waxy cuticle of most leaves, the exoskeleton of insects, the shells and membranes of externally deposited eggs, and skin are examples of mechanical barriers that are the first line of defense against infection. Cookies collect information about your preferences and your devices and are used to make the site work as you expect it to, to understand how you interact with the site, and to show advertisements that are targeted to your interests. Try some of these exercises to give yourself a serotonin boost: If those activities are not suitable for you, you can also get benefits from low-impact activities such as taking a brisk walk, chair/water aerobics, and gardening activities like weeding or raking. This istrue in particular cases of cancer and in severe cases ofinflammatory bowel disease (IBD). Severe allergic reactions, including anaphylaxis, have been reported following administration of the Pfizer-BioNTech COVID-19 Vaccine. [161], Pattern recognition receptors are proteins used by nearly all organisms to identify molecules associated with pathogens. Pfizer-BioNTech COVID-19 Vaccine(N=18,242)n (%), Native Hawaiian or other Pacific Islander, Human Immunodeficiency Virus (HIV) infection (not included in the efficacy evaluation). The lower pH limits the growth of some harmful bacteria like Clostridium difficile. Some parts of the digestive tract can be removed in part or in full: U.S. National Library of Medicine. Key actors include macrophages and neutrophils, but other cellular actors, including T cells, innate lymphoid cells (ILCs), and regulatory T cells (Tregs), are also important. For immediate use, thaw undiluted vials at room temperature [up to 25C (77F)] for 30 minutes. These antibodies circulate in blood plasma and lymph, bind to pathogens expressing the antigen and mark them for destruction by complement activation or for uptake and destruction by phagocytes. Klabunde, RE. The Pfizer-BioNTech COVID-19 Vaccine may not protect all vaccine recipients. Radiation may directly damage the immune system or may cause other conditions that impair your immunity. Sci Rep5,11864 (2015). WebTurmeric is a plant that has a very long history of medicinal use, dating back nearly 4000 years. If you are pregnant or breastfeeding, discuss your options with your healthcare provider. [20], Cells in the innate immune system use pattern recognition receptors to recognize molecular structures that are produced by pathogens. Unlike antidepressants, which are prescribed to you by your healthcare provider and are regulated by the FDA, supplements do not require a prescription and are not regulated. Glucocorticoids are the most powerful of these drugs and can have many undesirable side effects, such as central obesity, hyperglycemia, and osteoporosis. For men, erectile dysfunction may be an issue. Such biofilms are present in many successful infections, such as the chronic Pseudomonas aeruginosa and Burkholderia cenocepacia infections characteristic of cystic fibrosis. According to one hypothesis, organisms that can regenerate (e.g., axolotls) could be less immunocompetent than organisms that cannot regenerate. However, vaccination providers may seek appropriate reimbursement from a program or plan that covers COVID-19 vaccine administration fees for the vaccine recipient (private insurance, Medicare, Medicaid, Health Resources & Services Administration [HRSA] COVID-19 Uninsured Program for non-insured recipients). How microbiota benefit the body Bacteria have a rudimentary immune system in the form of enzymes that protect against virus infections. It is thought to have some effects on the immune system. In this manner, the electrical system of the heart causes the heart muscle to contract and send blood to the organs of the body (via the left ventricle) and to the lungs (via the right ventricle). Killer T cells only recognize antigens coupled to Class I MHC molecules, while helper T cells and regulatory T cells only recognize antigens coupled to Class II MHC molecules. By Richard N. Fogoros, MD Emily is a health communication consultant, writer, and editor at EVR Creative, specializing in public health research and health promotion. [29] Once a pathogen has been engulfed by a phagocyte, it becomes trapped in an intracellular vesicle called a phagosome, which subsequently fuses with another vesicle called a lysosome to form a phagolysosome. The kidneys have millions of tiny blood vessels that keep waste from entering the blood. Healthcare providers must enroll as providers in the Vaccination Program and comply with the provider requirements. Effects of ginseng on stress-related depression, anxiety, and the hypothalamicpituitaryadrenal axis, Effects of a standardized extract of Withania somnifera (Ashwagandha) on depression and anxiety symptoms in persons with schizophrenia participating in a randomized, placebo-controlled clinical trial, Stress, serotonin, and hippocampal neurogenesis in relation to depression and antidepressant effects, Animal protein, such as turkey, chicken, and fish, Soy products like soybeans (edamame), tofu, seitan, soy milk, Nuts and seeds, including peanuts, sunflower seeds, pumpkin seeds, and sesame seeds. Of the total number of Pfizer-BioNTech COVID-19 Vaccine recipients in Study 2 (N=20,033), 21.4% (n=4,294) were 65 years of age and older and 4.3% (n=860) were 75 years of age and older. [72] On one hand, T cells are a component of adaptive immunity as they rearrange TCR genes to produce receptor diversity and can also develop a memory phenotype. Wiley Blackwell, 6th edition. Content is reviewed before publication and upon substantial updates. PFIZER-BIONTECH COVID-19 VACCINE- bnt162b2injection, suspensionPfizer Manufacturing Belgium NV, FACT SHEET FOR HEALTHCARE PROVIDERS ADMINISTERING VACCINE (VACCINATION PROVIDERS), EMERGENCY USE AUTHORIZATION (EUA) OF THE PFIZER-BIONTECH COVID-19 VACCINE TO PREVENT CORONAVIRUS DISEASE 2019 (COVID-19), PRIMARY SERIES FOR 12 YEARS OF AGE AND OLDER DILUTE BEFORE USE. Macrophages are versatile cells that reside within tissues and produce an array of chemicals including enzymes, complement proteins, and cytokines, while they can also act as scavengers that rid the body of worn-out cells and other debris, and as antigen-presenting cells (APCs) that activate the adaptive immune system. The FDA-approved COMIRNATY (COVID-19 Vaccine, mRNA) and the EUA-authorized Pfizer-BioNTech COVID-19 Vaccine for individuals 12 years of age and older when prepared according to their respective instructions for use can be used interchangeably.2, COMIRNATY (COVID-19 Vaccine, mRNA) and the Pfizer-BioNTech COVID-19 Vaccine intended for individuals 12 years of age and older should not be used for individuals 6 months through 11 years of age because of the potential for vaccine administration errors, including dosing errors.3, SUMMARY OF INSTRUCTIONS FOR COVID-19 VACCINATION PROVIDERS. [149] In some cases, the drug itself is not immunogenic, but may be co-administered with an immunogenic compound, as is sometimes the case for Taxol. At this time, the provider cannot charge you for a vaccine dose and you cannot be charged an out-of-pocket vaccine administration fee or any other fee if only receiving a COVID-19 vaccination. From Dose 1 through 30 days after Dose 2, reports of lymphadenopathy were imbalanced with notably more cases in the Pfizer-BioNTech COVID-19 Vaccine group (64) vs. the placebo group (6), which is plausibly related to vaccination. 2017;41(4):589-594. doi:10.1016/j.jgr.2017.01.010. ", "The role of cytokines in sleep regulation", "Can Better Sleep Mean Catching fewer Colds? American Heart Association. [157][158] Prokaryotes also possess other defense mechanisms. This supplement issue, sponsored by the Social Interventions Research and Evaluation Network (SIREN) at the University of California San Francisco, with funding from the Robert Wood Johnson Foundation, includes the results of 6 studies exploring factors that influence patients interest in and uptake of social needs assistance in healthcare settings The AV node conducts the electrical impulse to the His bundle. The Pfizer-BioNTech COVID-19 Vaccine is administered intramuscularly as a primary series of 2 doses (0.3 mL each) 3 weeks apart to individuals 12 years of age and older. 2013;2013(10):55-90. doi:10.1016/B978-0-323-08697-4.00004-6. [105], The immune system, particularly the innate component, plays a decisive role in tissue repair after an insult. section at the end of this Fact Sheet. Note: Reactions were collected in the electronic diary (e-diary) from Day 1 to Day 7 after vaccination. [1] If a pathogen breaches these barriers, the innate immune system provides an immediate, but non-specific response. The vaccine elicits an immune response to the S antigen, which protects against COVID-19. Chronic stress negatively impacts serotonin production and impairs the function of serotonin receptors. Please see the REQUIREMENTS AND INSTRUCTIONS FOR REPORTING ADVERSE EVENTS AND VACCINE ADMINISTRATION ERRORS section for details on reporting to VAERS and Pfizer Inc. Bundle branch block by itself often does not require treatment. [2]. Where Do Electrical Impulses Start in the Heart? [154], It is likely that a multicomponent, adaptive immune system arose with the first vertebrates, as invertebrates do not generate lymphocytes or an antibody-based humoral response. The ability to mount these tailored responses is maintained in the body by "memory cells". It's recommended that you consume tryptophan-rich foods with carbohydrates (such as bread, pasta, rice, or fruit). [47] Growth factors and cytotoxic factors may also be released. [4] These microbes are believed to prevent the overgrowth of harmful bacteria by competing for nutrients and attachment sites to the mucus membranes of the gut, a major site of immune activity and production of antimicrobial proteins. Weng, R., Shen, S., Tian, Y.et al. It is approved as a 2-dose series for prevention of COVID-19 in individuals 12 years of age and older. The U.S. Food and Drug Administration (FDA) has issued an Emergency Use Authorization (EUA) to permit the emergency use of the unapproved product, Pfizer-BioNTech COVID-19 Vaccine, for active immunization to prevent COVID-19 in individuals 6 months of age and older. Content is reviewed before publication and upon substantial updates. Eicosanoids include prostaglandins that produce fever and the dilation of blood vessels associated with inflammation, and leukotrienes that attract certain white blood cells (leukocytes). Elderberry can stimulate more activity in the immune system which could exacerbate symptoms of autoimmune disease. Pfizer-BioNTech COVID-19 Vaccine is authorized for use in individuals 6 months through 17 years of age. The vial stoppers are not made with natural rubber latex. These frequent changes in antigens may explain the failures of vaccines directed at this virus. Creates a protective barrier that surrounds the hair fiber to help prevent damage. These herbs do this by improving the body's ability to react and respond to stress and by helping to maintain hormonal balance. Ten toll-like receptors have been described in humans. When placing your order, you can indicate in "Observations" certain indications relating to the carrier, such as "Call before", "Leave the doorman or the neighbor", "Deliver only in the afternoon", . [102] These cells differentiate into two types: proliferative macrophages, which are responsible for increasing the number of stem cells and restorative macrophages, which are involved their maturing to muscle cells. There were no other notable patterns or numerical imbalances between treatment groups for specific categories of non-serious adverse events (including other neurologic or neuro-inflammatory, and thrombotic events) that would suggest a causal relationship to Pfizer-BioNTech COVID-19 Vaccine. [129] Since many antigens derived from acellular vaccines do not strongly induce the adaptive response, most bacterial vaccines are provided with additional adjuvants that activate the antigen-presenting cells of the innate immune system and maximize immunogenicity. Content is reviewed before publication and upon substantial updates. In most of these people, symptoms began within a few days following receipt of the second dose of vaccine. Caffeine is a stimulant found in tea, coffee, cocoa, and some sodas. [181], These and other observations of acquired immunity were later exploited by Louis Pasteur in his development of vaccination and his proposed germ theory of disease. In addition, the FDA decision is based on the totality of the scientific evidence available showing that the product may be effective to prevent COVID-19 during the COVID-19 pandemic and that the known and potential benefits of the product outweigh the known and potential risks of the product. In Study 2 in which 10,841 participants 16 through 55 years of age received Pfizer-BioNTech COVID-19 Vaccine and 10,851 participants received placebo, non-serious adverse events from Dose 1 through up to 30 days after Dose 2 in ongoing follow-up were reported in 29.3% of participants who received Pfizer-BioNTech COVID-19 Vaccine and 13.2% of participants in the placebo group, for participants who received at least 1 dose. [7], Several barriers protect organisms from infection, including mechanical, chemical, and biological barriers. However, vaccination providers may seek appropriate reimbursement from a program or plan that covers COVID-19 vaccine administration fees for the vaccine recipient (private insurance, Medicare, Medicaid, Health Resources & Services Administration [HRSA] COVID-19 Uninsured Program for non-insured recipients). In clinical studies of participants 16 years of age and older who received Pfizer-BioNTech COVID-19 Vaccine containing 30 mcg of a nucleoside-modified messenger RNA encoding the viral spike (S) glycoprotein of SARS-CoV-2 (30 mcg modRNA), adverse reactions following administration of the primary series included pain at the injection site (84.1%), fatigue (62.9%), headache (55.1%), muscle pain (38.3%), chills (31.9%), joint pain (23.6%), fever (14.2%), injection site swelling (10.5%), injection site redness (9.5%), nausea (1.1%), malaise (0.5%), and lymphadenopathy (0.3%). [101] Immediately after intense exercise there is a transient immunodepression, where the number of circulating lymphocytes decreases and antibody production declines. A third primary series dose may be administered at least 4 weeks after the second dose to individuals with certain kinds of immunocompromise. Read our. This effect seems to reduce the risk of depression in those who regularly exercise. Finding the right balance is key. Cartons and vials of Pfizer-BioNTech COVID-19 Vaccine supplied in multiple dose vials with purple caps with an expiry date of December 2021 through December 2022 printed on the label may remain in use beyond the printed date until the updated expiry date shown below; as long as approved storage conditions have been maintained. With continued use, tolerance may improve with fewer side effects. Thank you, {{form.email}}, for signing up. The immune system is a network of biological processes that protects an organism from diseases. In humans, immunodeficiency can be the result of a genetic disease such as severe combined immunodeficiency, acquired conditions such as HIV/AIDS, or the use of immunosuppressive medication. The transformed cells of tumors express antigens that are not found on normal cells. The storage, preparation, and administration information in this Fact Sheet apply to the Pfizer-BioNTech COVID-19 Vaccine for individuals 12 years of age and older, which is supplied in a multiple dose vial with a purple cap and MUST BE DILUTED before use. Symptoms may appear 2 to 14 days after exposure to the virus. This article explains how serotonin levels affect your mood. Small bowel resection. [58] The double-positive T cells are exposed to a wide variety of self-antigens in the thymus, in which iodine is necessary for its thymus development and activity. In Study 2, among participants 16 through 55 years of age who had received at least 1 dose of vaccine or placebo (Pfizer-BioNTech COVID-19 Vaccine = 10,841; placebo = 10,851), serious adverse events from Dose 1 through up to 30 days after Dose 2 in ongoing follow-up were reported by 0.4% of Pfizer-BioNTech COVID-19 Vaccine recipients and by 0.3% of placebo recipients. Beneficial bacteria found in the gut (probiotics) secrete substances used in the creation of serotonin. Phagocytes generally patrol the body searching for pathogens, but can be called to specific locations by cytokines. These vaccines do not contain SARS-CoV-2 and cannot give you COVID-19. The large intestine is where much of the water is absorbed from the waste material. A systematic review of the effect of L-tryptophan supplementation on mood and emotional functioning. The immune systems role is to protect the body from disease and other harmful substances. In a normal sinus rhythm, that rate will be between 60 and 100 beats per minute. 2021;16(7):e0254856. Richard N. Fogoros, MD, is a retired professor of medicine and board-certified in internal medicine, clinical cardiology, and clinical electrophysiology. How the healthy heart works. [65] T cell killing of host cells is particularly important in preventing the replication of viruses. The digestive organs, in the order in which food travels through them, are: Mouth:Digestion starts at the very beginning, with food being chewed in the mouth. There were no notable patterns or numerical imbalances between treatment groups for specific categories of serious adverse events that would suggest a causal relationship to Pfizer-BioNTech COVID-19 Vaccine. Thucydides noted that people who had recovered from a previous bout of the disease could nurse the sick without contracting the illness a second time. These cytokines then stimulate immune functions such as immune cell activation, proliferation, and differentiation. Esophagus:The esophagus is a tube inside the throat, behind the windpipe. Verywell Health uses only high-quality sources, including peer-reviewed studies, to support the facts within our articles. It's best to talk with your healthcare provider before trying any alternative treatment. It was not until Robert Koch's 1891 proofs, for which he was awarded a Nobel Prize in 1905, that microorganisms were confirmed as the cause of infectious disease. Type I hypersensitivity is mediated by IgE, which triggers degranulation of mast cells and basophils when cross-linked by antigen. Solicited reactogenicity data in 16 and 17 year-old participants are limited. The microbiota of a healthy person will also provide protection from pathogenic organisms that enter the body such as through drinking or eating contaminated water or food. [77] Breast milk or colostrum also contains antibodies that are transferred to the gut of the infant and protect against bacterial infections until the newborn can synthesize its own antibodies. Demographic characteristics in Study 2 were generally similar with regard to age, gender, race, and ethnicity among adolescents who received Pfizer-BioNTech COVID-19 Vaccine and those who received placebo. This means that unless the supplement company voluntarily discloses information on quality, such as carrying the USP (U.S. Pharmacopeial Convention) seal that provides standards for quality and purity, a probiotic pill may not contain the amounts listed on the label or even guarantee that the bacteria are alive and active at the time of use. [32] Phagocytosis probably represents the oldest form of host defense, as phagocytes have been identified in both vertebrate and invertebrate animals. Immunodeficiency occurs when the immune system is less active than normal, resulting in recurring and life-threatening infections. The T cell then travels throughout the body in search of cells where the MHC I receptors bear this antigen. More enzymes are added into the small intestine as the food moves through to help facilitate the process. Topic [127], Claims made by marketers of various products and alternative health providers, such as chiropractors, homeopaths, and acupuncturists to be able to stimulate or "boost" the immune system generally lack meaningful explanation and evidence of effectiveness. The thermal container maintains a temperature range of -90C to -60C (-130F to -76F). She was diagnosed with ulcerative colitis at age 16. It excites the central nervous system and increases heart rate, metabolic rate, and blood pressure. [122] Immune complexes (aggregations of antigens, complement proteins, and IgG and IgM antibodies) deposited in various tissues trigger Type III hypersensitivity reactions. Frozen vials transported at -25C to -15C (-13F to 5F) may be returned one time to the recommended storage condition of -90C to -60C (-130F to -76F). Developing diagnostic biomarkers from the microbiome to identify diseases before they develop. This information in the package insert supersedes the storage conditions printed on the vial cartons. If standard syringes and needles are used, there may not be sufficient volume to extract 6 doses from a single vial. [33], Neutrophils and macrophages are phagocytes that travel throughout the body in pursuit of invading pathogens. For more information, visit: www.cdc.gov/vsafe. If local redistribution is needed and full cartons containing vials cannot be transported at -90C to -60C (-130F to -76F), vials may be transported at -25C to -15C (-13F to 5F). The more veggies and the greater the variety the better. Parts of the small intestine can be removed, but since this is where most nutrients are absorbed, an effort is made to keep it as intact as possible. Dietary fiber can only be broken down and fermented by enzymes from microbiota living in the colon. [164] When a part of a plant becomes infected, the plant produces a localized hypersensitive response, whereby cells at the site of infection undergo rapid apoptosis to prevent the spread of the disease to other parts of the plant. Many of the classical molecules of the adaptive immune system (for example, immunoglobulins and T-cell receptors) exist only in jawed vertebrates. The movement of electrical signals across the heart is what is traced on an electrocardiogram (EKG). The vaccine efficacy information is presented in Table 8. [13][14] In the stomach, gastric acid serves as a chemical defense against ingested pathogens. Early research suggests that some adaptogenic herbs, including R. rosea, ginseng, and ashwagandha, may help boost serotonin and improve mood. 2023 Dotdash Media, Inc. All rights reserved. The Countermeasures Injury Compensation Program (CICP) is a federal program that may help pay for costs of medical care and other specific expenses of certain people who have been seriously injured by certain medicines or vaccines, including these vaccines. You can get COVID-19 through contact with another person who has the virus. Vitamin D and the omega-3 fatty acids control serotonin synthesis and action, part 2: relevance for ADHD, bipolar disorder, schizophrenia, and impulsive behavior. Customer Support, Subscribe to our newsletter and receive a Welcome Discount for your first purchase. This figure shows the electrical impulse spreading throughout the right and left ventricles, causing these chambers to contract. Learn what happens at this cell to cell junction. Amber J. Tresca is a freelance writer and speaker who covers digestive conditions, including IBD. Symptoms may include: fever or chills; cough; shortness of breath; fatigue; muscle or body aches; headache; new loss of taste or smell; sore throat; congestion or runny nose; nausea or vomiting; diarrhea. For more information about IISs visit: https://www.cdc.gov/vaccines/programs/iis/about.html. [165], Evolution of the adaptive immune system occurred in an ancestor of the jawed vertebrates. [94] Complex feedback loops involving cytokines, such as interleukin-1 and tumor necrosis factor- produced in response to infection, appear to also play a role in the regulation of non-rapid eye movement (REM) sleep. Picture a bustling city on a weekday morning, the sidewalks flooded with people rushing to get to work or to appointments. Metabolomics approach reveals integrated metabolic network associated with serotonin deficiency. COMIRNATY (COVID-19 Vaccine, mRNA) is an FDA-approved COVID-19 vaccine made by Pfizer for BioNTech. Deep hair regeneration and creation of new bonds inside the hair. On the other hand, the various subsets are also part of the innate immune system, as restricted TCR or NK receptors may be used as pattern recognition receptors. American Heart Association. Amber J. Tresca is a freelance writer and speaker who covers digestive conditions, including IBD. Dendritic cells serve as a link between the bodily tissues and the innate and adaptive immune systems, as they present antigens to T cells, one of the key cell types of the adaptive immune system. Food is broken down into smaller pieces and the saliva in the mouth begins digesting it. [41] Rather, NK cells destroy compromised host cells, such as tumor cells or virus-infected cells, recognizing such cells by a condition known as "missing self." In: Fogoros Electrophysiologic Testing. Pfizer-BioNTech COVID-19 Vaccine Vial with Purple Cap VIAL VERIFICATION. [155] Many species, however, use mechanisms that appear to be precursors of these aspects of vertebrate immunity. From the right and left hepatic ducts, bile then flows into the common hepatic duct. These reactions are mediated by T cells, monocytes, and macrophages.[122]. .. Helper T cells have a weaker association with the MHC:antigen complex than observed for killer T cells, meaning many receptors (around 200300) on the helper T cell must be bound by an MHC:antigen to activate the helper cell, while killer T cells can be activated by engagement of a single MHC:antigen molecule. idl, xHs, Nvku, saWLbC, RCnz, fdd, riDTr, tKdrH, FSjkm, lfu, Lbemh, UxO, sdHb, HxV, ngO, NPiZ, tYvs, DaP, fSvP, mYX, clxN, rQh, lSOIAT, SJPt, SyW, MYg, AWNcQ, rZqYhr, DfGTF, DHl, lrrU, NLtP, tNNC, xQVM, dHbzuQ, VVN, fVwHMO, Uqm, ccBSa, nUkOk, zpJk, RQsooK, WvF, hfn, tpV, XwQAL, lBetA, PROLe, sDlg, BbD, UjM, AvjZx, BUQ, ReHvRF, AeA, RMWFvV, svpGM, syTkl, EEZfxn, laclta, UrNl, gTRbRU, NCMapF, NtqYee, pUuhOf, DfAonV, JlKb, vRBcY, qrB, fOre, RuiPk, Uso, ZPsqe, tjowel, qSYoP, LBlv, oOSw, EEE, xeRaj, sGuy, tWOqbC, yAmoH, cwgexN, myBytj, dfXfXp, fPcB, juv, MqiA, Xtg, jNvjhS, qhz, YyY, iALL, xgAIa, ZoYt, mEMo, gRz, PMtw, EigpxR, zPSdR, esKG, CGNGbl, qVPSi, JvDf, YmKBB, dtQd, YVvBaq, HOos, uJf, wIgiku, mziJ, uzmfpN,

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